Human cannabinoid receptor genes

Caenazzo L, Hoehe M, Hsieh W, Berrettini W, Bonner T, Gershon E (1991) Hindi I identifies a two aUele DNA polymorphism of the human cannabinoid receptor gene (CNR). Nucleic Acids Res 19 4798... 

Hoehe, M.R., Caenazzo, L., Martinez, M.M., Hsieh, W-T., Modi, W.S., Gershon, E.S., Bonner T.I. (1991) Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6ql4-ql5. New Biol. 3, 880-885. 

Gadzicki D, Miiller-Vahl K, Stuhrmann M (1999) A frequent polymorphism in the coding exon of the human cannabinoid receptor (CNR1) gene. Mol Cell Probes 13 321-323... 

Jbilo O, Derocq J-M, Segui M, Le Fur G, Casellas P (1999) Sdmula-don of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocydc cell line HL60. FEBS Lett 448 273-277. 

There is accumulating physiological evidence for the existence of otlier distinct functional cannabinoid receptors different from the currently known CBj and CBj CBRs that are putatively referred to as CBj, CB4, CBj, CBg, CB, CBg, CBg, CBjq, CBu, CBjj, CBjj. .. CB. Whereas the molecular identities of other unknown cannabinoid receptors have been elusive, recent characterization of the human CBjR gene indicates many structural feamres and splice variants that may be involved in the actions of smoked marijuana. The emerging fimctional evidences for the existence of putative CB3, CB4, CBj, CBg, CB, CBg, CBg, CBjq, CBjj, CBjj, CBjj. .. CB cannabinoid receptors are randomly classified below until their molecular identity is known ... 

Synthesis of novei cannabinoids as targets for CNS disorders Focus on human genes that encode cannabinoid receptors and contribute to addiction... 

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