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HPMA copolymer-platinate

HPMA copolymer-platinate Phase I Access Pharmaceuticals123... [Pg.98]

Figure 13 HPMA copolymer platinate AP5280 (32) x = 90 mol%, y = 10mol%... Figure 13 HPMA copolymer platinate AP5280 (32) x = 90 mol%, y = 10mol%...
Gianasi E, Wasil M, Evagorou EG, et al. HPMA copolymer platinates as novel antitumor agents in vitro properties, pharmacokinetics, and antitumor activity. Eur J Cancer 1999 3 994-1002. [Pg.395]

Gianasi E, et al. HPMA copolymers platinates containing dicarboxylato ligands. Preparation, characterisation and in vitro and in vivo evaluation, J Drug Targeting 2002, 10, 549-556. [Pg.1386]

Figure 7 Release of platinates from HPMA copolymer-platinates in vitro. Panel (a) release in phosphate buffered saline (pH 7.4) panel (b) release in citrate phosphate buffer (pH 5.5). HPMA copolymer-Gly-Phe-Leu-Gly-en-Pt (A—A) HPMA copolymer-Gly-Gly-en-Pt (O—O) HPMA copolymer-Gly-Phe-Leu-Gly-COO-Pt (A—A) HPMA copolymer-Gly-Gly-COO-Pt ( — ). (From Ref. 90.)... Figure 7 Release of platinates from HPMA copolymer-platinates in vitro. Panel (a) release in phosphate buffered saline (pH 7.4) panel (b) release in citrate phosphate buffer (pH 5.5). HPMA copolymer-Gly-Phe-Leu-Gly-en-Pt (A—A) HPMA copolymer-Gly-Gly-en-Pt (O—O) HPMA copolymer-Gly-Phe-Leu-Gly-COO-Pt (A—A) HPMA copolymer-Gly-Gly-COO-Pt ( — ). (From Ref. 90.)...
Figure 11 Facingpage) HPMA copolymer-anticancer conjugates demonstrate improved targeting of chemotherapy to an sc B16F10 solid tumor models in vivo. The data shown represent the time-dependent accumulation of (a) PKl and free doxorubicin and (b) HPMA copolymer-platinate. (From Refs. 90,188.)... Figure 11 Facingpage) HPMA copolymer-anticancer conjugates demonstrate improved targeting of chemotherapy to an sc B16F10 solid tumor models in vivo. The data shown represent the time-dependent accumulation of (a) PKl and free doxorubicin and (b) HPMA copolymer-platinate. (From Refs. 90,188.)...
Gianasi E, Buckley RG, Latigo J, Wasil M, Duncan R. HPMA copolymers platinates containing dicarboxylato ligands. J Drug Target 2002 10 549-556. [Pg.70]

Nowotnik DP. Preclinical development and Phase I results with HPMA copolymer platinates. Proceedings of the Sixth International Symposium on Polymer Therapeutics From Laboratory to Clinical Practice, Cardiff, UK, January 7-9, 2004. [Pg.89]

HPMA copolymer- platinate (Malonate) AP5280 Access Pharmaceuticals Inc. Phase I/II [91,117,118]... [Pg.20]

Fig. 8 a HPMA copolymer-platinate (AP5280) b HPMA copolymer-platinate (AP5346)... [Pg.32]

A second lead HPMA copolymer-platinate (AP5346) has been identified with a similar Gly-Phe-Leu-Gly-aminomalonate side chain, but in this case terminating in a 1,2-diaminocyclohexyl (DACH) palatinate (Fig. 8). hi Phase 1 clinical trial, it was administered as intravenous infusion of 80-1280 mg Pt/m once a week in 28-day cycle to patients with a broad cross-section of tumour types. Out of the 12 evaluable patients, one demonstrated a partial response. Dose hmiting toxicity was neutropenia but also nausea, vomiting, asthenia, fatigue and diarrhoea were observed (as presented in October 2004 at the 16th... [Pg.32]

Gianasi, E., Wasil, M., Evagorou, E. G., Keddle, A., Wilson, G. and Duncan, R. (1999) HPMA copolymer platinates as novel antitumour agents In vitro properties, pharmacokinetics and antitumour activity in vivo. Eur J Cancer, 35, 994-1002. [Pg.351]

See other pages where HPMA copolymer-platinate is mentioned: [Pg.8]    [Pg.15]    [Pg.25]    [Pg.54]    [Pg.55]    [Pg.282]    [Pg.49]    [Pg.31]    [Pg.31]    [Pg.105]    [Pg.31]    [Pg.31]    [Pg.282]    [Pg.160]   


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HPMA copolymer

Platinate

Platination

Platinic

Platinization

Platinized

Platinizing

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