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HPMA copolymer-antibody-doxorubicin conjugates

Rihova, Ulbrich and colleagues have reported preliminary chnical experiments in six patients with refractory disease (angiosarcoma, and breast carcinoma) [107,108]. HPMA coplymer-Gly-Phe-Leu-Gly-doxorubicin (or [Pg.26]

Kovar M, Strohalm J, Etrych T, Ulbrich K, Rihova B. Star structure of antibody-targeted HPMA copolymer-bound doxorubicin. A novel type of pol3uneric conjugate for targeted drug delivery with potent antitumour effect. Bioconj Chem 2002 13 206-215. [Pg.78]

Jelinkova, M., Strohalm, J., Plocova, D., et al. Targeting of human and mouse T-lym-phocytes by monoclonal antibody-HPMA copolymer-doxorubicin conjugates directed against different T-cell surface antigens. J. Cont. Rel. 52 253-270, 1998. [Pg.401]

Fig. 14 A Polymer directed enzyme prodrug therapy (PDEPT) is a two-step approach that relies on activation of a polymer-drug conjugate by a complementary polymer-enzyme conjugate B PKl activated HPMA copolymer-Gly-Gly-cathepsin B C HPMA copolymer-Gly-Gly-cephalosporin-doxorubicin activated by HPMA copolymer-Gly-Gly-/3-lactamase D Etoposide prodrug (candidate for polymer conjugation) activated by HPMA copolymer-catalytic antibody 38C2... Fig. 14 A Polymer directed enzyme prodrug therapy (PDEPT) is a two-step approach that relies on activation of a polymer-drug conjugate by a complementary polymer-enzyme conjugate B PKl activated HPMA copolymer-Gly-Gly-cathepsin B C HPMA copolymer-Gly-Gly-cephalosporin-doxorubicin activated by HPMA copolymer-Gly-Gly-/3-lactamase D Etoposide prodrug (candidate for polymer conjugation) activated by HPMA copolymer-catalytic antibody 38C2...
See other pages where HPMA copolymer-antibody-doxorubicin conjugates is mentioned: [Pg.26]    [Pg.26]    [Pg.26]    [Pg.26]    [Pg.30]    [Pg.57]    [Pg.119]    [Pg.20]    [Pg.30]    [Pg.31]    [Pg.36]    [Pg.39]    [Pg.43]    [Pg.77]    [Pg.27]    [Pg.27]   
See also in sourсe #XX -- [ Pg.26 ]

See also in sourсe #XX -- [ Pg.26 ]



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Antibodies conjugation

Antibody conjugates

Copolymers conjugated

Doxorubicin

Doxorubicin antibody conjugates

Doxorubicin conjugate

Doxorubicine

HPMA copolymer

HPMA copolymer conjugates

HPMA copolymer-antibody-doxorubicin

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