HPLC coupled with ICP spectrometric detection

The ICP is more compatible with LC than the MIP since the higher power can easily cope with liquid sample introduction. An HPLC system can be very easily coupled to an ICP by connecting the column outlet to the ICP nebuliser using a short piece of tubing (Ibrahim et al., 1984) The tubing should be as short as possible to maintain good resolution. The problem with this system is that the ICP nebuliser is very inefficient and instead of 100% transfer of analyte into the plasma this is usually only between 1% and 20%. This has a major effect on 

Sample Elements Species Separation process interface Limits of detection Reference 

Plaice, oysters, mussel samples Arsenic Nine organic arsenic species HPLC with ion spray, MS-MS 0.09jug g 1 tetramethylarsonium ion by MS-MS Corr and Larsen (1996) 

Urine samples Arsenic Ten organoarsenic compounds Microbore HPLC, ES-MS-MS 2-21 pg As (positive ion mode) Pergantis et al. (1997) 

Surface waters and sediments Tin Triphenyltin compounds MS-MS 500 ng absolute as Sn Miermans et al. (1997) 

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