How Little We Know

Principles of Psychopharmacology for Mental Health Professionals By Jeffrey E. Kelsey, D. Jeffrey Newport, and Charles B. Nemeroff Copyright 2006 John Wiley Sons, Inc. 

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Tables 1-1, 1-2, 1-3, and 1-4 show how little we know about the levels of 1,2-diphenylhydrazine that might affect your health. As is shown in Table 1-4, animals that ate food containing 1,2-diphenylhydrazine for a long time developed lung inflammation, stomach damage, and liver damage, and some died. Although the levels of exposure that cause harmful effects in humans are not known, as discussed in Section 1.2, 1,2-diphenylhydrazine is not likely to be found in food, and you are not even likely to be exposed to levels of concern if you live near a hazardous waste site. Additional information on levels of exposure associated with effects can he found in Chapter 2.

The fact that, working with these liposome systems, new things are always being discovered, is pleasant, but it also reveals how little we know about their thermodynamic and kinetic properties. It would have been impossible to predict the... 

Beutler, E. (1997). How little we know about the absorption of iron. Am. /. Cfin. Nutr. 66, 419-420. 

In February 1985, the Cornell University Ecosystems Research Center issued one of the first comprehensive overviews of what was possible and what was lacking to adequately assess the environmental risks of new biotechnology products. The findings of that report are still quite remarkable, and underscore how little we know about microorganisms—how they survive, how they are dispersed in the environment, why some grow rapidly, and why others do not. 

This comparatively brief discussion of the role of organic matter in disease control emphasizes how little we know about the subject, and the difficulties of conducting research in this field. This is because we must deal, ultimately at least, with the whole field of ecology that involves all living organisms present in and on the soil, all factors... 

What this study does emphasize, though, is (1) how important trace metals such as iron are in the biology of the marine environment and (2) how little we know about the bioinorganic chemistry, as well as the ecology, of these environments. There s a lot for a young chemist to tackle ... 

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