How Is Arachidonate Transported Within Cells

A family of cytosolic proteins have been identified which bind long-chain fatty acids, including arachidonic acid, with high affinity (dissociation constants are in the range of 0.1-2 These 

Interestingly, this tridimensional conformation is similar to that of extracellular lipocalins, whose amino acid sequences share no similarity with those of cytosolic FABP.  

Because of their binding to long-chain fatty acids and of their highly regulated expression in tissues, FABP are thought to play a central role in the uptake and transport of fatty acids, and possibly in other aspects of the biological actions and metabolism of these lipids. Indeed, FABP have been shown, in vitro, to transfer 

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