How Do Soluble Proteins Compensate for Their Wrapping Defects

1 How Do Soluble Proteins Compensate for Their Wrapping Defects [Pg.17]

A thorough examination of the protein data bank (PDB) singles out toxin peptides with picomolar affinity for the Kvl.3 potassium channel [6], such as HsTXl (PDB.1QUZ), as members of the protein family with the highest extent of structural [Pg.17]

Fernandez, Transformative Concepts for Drug Design Target Wrapping, 17 [Pg.17]

A separate analysis reveals that such proteins contain an inordinately large number of disulfide bonds, with an average of 11 when normalized to 100 amino acids. These observations prompt us to investigate the relation between structural deficiency and disulfide bonds in search for a balance equation that reflects a statistical correlation between structural strengths and vulnerabilities of soluble proteins and polypeptides. The balance equation unraveled in this chapter is likely to impact the design of soluble proteins and enable a better control of their functional modulation in relation to environmental redox conditions. [Pg.18]

PDB entry Disulfide bonds Chain length Structural deficiencies Backbone HBs X Y Non-a/fS residues (%) [Pg.18]

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