Host/guest design

Fig. 18. Crystal structures of recent clathrate design (a) coordinatoclathrate between host (39) (Fig. 17) and / -butanol (host—guest hydrogen bonding in the shaded area) (b) perspective view of the hehcal inclusion channel formed by diol host (43) (Fig. 17 all except one host molecule are represented...

Baars MWPL, Meijer EW (2000) Host-Guest Chemistry of Dendritic Molecules. 210 131-182 Balczewski P, see Mikoloajczyk M (2003) 223 161-214 Ballauff M (2001) Structure of Dendrimers in Dilute Solution. 212 177-194 Baltzer L (1999) Functionalization and Properties of Designed Folded Polypeptides. 202 39-76 Balzani V, Ceroni P, Maestri M, Saudan C, Vicinelli V (2003) Luminescent Dendrimers. Recent Advances. 228 159-191 Barre L, see Lasne M-C (2002) 222 201-258 Bartlett RJ, see Sun J-Q (1999) 203 121-145... 

The shape-persistent, structurally well-defined nature of PAMs and PDMs make them attractive models for binding guest molecules within their cavities. In 1995, Hoger and Enkelmann reported the construction of the first meta/para-PAM/PDM hybrid designed to possess hydrophobic and hydrophilic substituents for subsequent use in host guest chemistry [71]. Macrocyclic amphiphile 116 was assembled via the straightforward manner depicted in Scheme 26. 

Furthermore, polymantanes have the potential to be utilized in the rational design of multifunctional drug systems and drug carriers. In host-guest chemistry, there is plenty of room for working with diamondoids. 

The wheel-and-axle design as source for host-guest compounds was originally proposed by Toda and Hart in 1981 for hosts containing hydroxyl functions 481 (see Ch. 3, Sect. 2.1 of Vol. 140). The l,l,6,6-tetraphenylhexa-2,4-diyne-l,6-diol (24) provides a representative compound. It forms 1 2 crystalline inclusion complexes with a large number of small guest molecules, including a variety of ketones, amines, amides and a sulfoxide 48). 

Collet, A., Dutasta, J.-P., Lozach, B., and Canceill, J. Cyclotriveratrylenes and Cryptophanes Their Synthesis and Applications to Host-Guest Chemistry and to the Design of New Materials. 165, 103-129 (1993). 

In host-guest systems based on electron donor/ acceptor interactions, association/dissociation can be driven by redox processes so that it is possible to design electrochemical switches than can be used to control energy- and electron-transfer processes. 

T. Thoms, S. Okada, J. Chen, and M. Furugori, Improved host material design for phosphorescent guest-host systems, Thin Solid Films, 436 264—268 (2003). 

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