Hormone-responsive genes

There have been a number of technological advances in recent years which are responsible for much of the progress made in our understanding of steroid receptor mechanisms. These include the ability to purify receptors, affinity labeling techniques, production of antireceptor antibodies for direct detection of receptor proteins, and isolation and characterization of hormone responsive genes as well as the genes for receptors themselves. 

Steroid receptors control gene expression in target cells. An understanding of the molecular interactions between receptors and specific nuclear components is crucial for elucidating the mechanism of hormone action. Receptor binding to at least three structural elements of nuclei has been described. These include the nuclear matrix, nucleoacidic chromatin proteins (acceptor proteins), and specific DNA sequences in 5 upstream elements of hormone responsive genes. 

Plant hormones are known to exert their effects on plant development by altering the expression of specific genes. A wide range of hormone responsive genes have been... 

Wauthier V, Waxman DJ (2008) Sex-specific early growth hormone response genes in rat liver. Mol Endocrinol 22 1962-1974... 

---