Hormonal Regulation of Kallikreins

Steroid hormones, acting through their receptors, play important roles in the normal development and function of many organs. In addition, they are involved in the pathogenesis of many types of cancer [146], Several reports confirmed that many kallikreins are under steroid hormone regulation in endocrine-related tissues and cell lines [100, 147-155], 

Recently, Palmer et al., working with human colon cancer cell lines, reported dramatic up-regulation of kallikreins 6 and 10 by la, 25-dihydroxyvitamin D3 [158]. This finding raises the possibility that some kallikreins could be regulated by a multitude of nuclear receptors. 

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