Homologous sequences detection

Fomenko, D.E., Xing, W., Thomas, D.J. and Gladyshev, V.N. (2007) Large-scale identification of catalytic redox-active cysteines by detecting sporadic cysteine/selenocysteine pairs in homologous sequences. Science, 315, 387-89. 

Multiple sequence alignment in Homology unsurprisingly detected no significant homology in this portion of JHE when compared with either template. However, it has been reported that despite a low sequence similarity in the C-terminal... 

We demonstrate the latter approaeh on a small protein domain, which is homologous to proteins that are present in the protein data bank [86], As can be nicely seen in Fig. 55, rhodniin, which is homologous to other Kazal-type inhibitors, is found in the protein data bank. Here, the sequence homology is quite high. However, also structures with almost no sequence homologies are detected, as is the case for dihydrofolate reductase and D-xylose isomerase. 

K Sjdlander, K Karplus, M Brown, R Hughey, A Krogh, IS Mian, D Haussler. Dirichlet mixtures A method for improved detection of weak but significant protein sequence homology. Comput Appl Biosci 12 327-345, 1996. 

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