Hofrichter

Hofrichter J, Sommer J H, Henry E R and Eaton W A 1983 Nanosecond absorption spectroscopy of haemoglobin Proc. Natl Acad. Scl. USA 80 2235-9... 

Hoffmann, H., Wagner, J., Hofrichter, G. and Grill, H. U.S. Patent 3,839,587 October 1, 1974 assigned to Chemisch-Pharmazeutische Fabrik Adolf Klinge and Co. 

The metabolic activity of other white-rot fungi including Phanerochaete chrysosporium and Pleurotus ostreacus has been discussed in the context of polycyclic aromatic hydrocarbons. For example, the mineralization potential of the manganese peroxide system fmmNematolomafrowardii for a number of substrates has been demonstrated (Hofrichter et al. 1998) the formation of CO2 from labeled substrates ranged from 7% (pyrene) to 36% (pentachlorophenol), 42% (2-amino-4, 6-dinitrotoluene), and 49% (catechol). 

Hofrichter M, K Scheibner, 1 Schneega, W Fritsche (1998) Enzymatic combusion of aromatic and aliphatic compounds by manganese peroxidase from Nematoloma frowardii. Appl Environ Microbiol 64 399-404. 

Steffen KT, A Hatakka, M Hofrichter (2003) Degradation of benzo[a]pyrene by the litter-decomposing basid-iomycete Stropharia coronilla role of manganese peroxidase. Appl Environ Microbiol 69 3957-3963. 

Sack M Hofrichter, W Fritsche (1997) Degradation of phenanthrene and pyrene by Nematoloma frowardii. J Basic Microbiol 4 287-293. 

Ferrone FA, Hofrichter J, Eaton WA. Kinetics of sickle hemoglobin polymerization II. A double nucleation mechanism. J Mol Biol 1985 183 611-633. 

Eaton WA, Hofrichter J. The biophysics of sickle cell hydroxyurea therapy. Science 1995 268 1142-1143. 

Hofrichter M, Ullrich R, Pecyna MJ, Liers C, Lundell T (2010) Appl Microbiol Biotechnol 87 871... 

Hatakka A (2001) In Hofrichter M, Steinbiichel A (eds) Biopolymers lignin, humic substances and coal, 1st edn. Wiley-VCH, Weinheim, p 129... 

Steffen KT, Hofrichter M, Hatakka A (2000) Appl Environ Microbiol 54 819... 

Kabiersch G, Rajasarkka J, Ullrich R, Tuomela M, Hofrichter M, Virta M, Hatakka A, Steffen K (2011) Chemosphere 83 226... 

Hofrichter, M., and Fritsche, W., Depolymerization of Low Rank Coal by Extracellular Fungal Enzyme Systems. 1. Screening for Low Rank-Coal-Depolymerizing Activities. Applied Microbiology and Biotechnology, 1996. 46(3) pp. 220-225. 

Scheibner K, Hofrichter M, Fritsche W (1997) Mineralization of 2-amino-4, 6-dinitrotoluene by manganese peroxidase of the white-rot fungus Nematoloma frowardii. Biotechnol Lett... 

From this type of analysis, one would conclude that t must be approximately 28 for a 10% reduction in protomer to cause a 95% reduction in the nucleus concentration. This is a rather startling apparent reaction order even assuming infinite cooperativity between protomers. It is recalled that Hofrichter et al. (1974) found from a similar analysis of the rate of nucleation of human hemoglobin S (HbS) at 30 C that the apparent reaction order for the nucleation of HbS aggregation was about 32. Of course, such analyses are not fully justifiable because one may not assume ideality in the solution properties of biopolymers at high concentrations, particularly at 200 mg/ml in the case of hemoglobin. The computation for the case of tubulin polymerization does, nonetheless, emphasize that nucleation would be an especially cooperative event if only tubulin, and not ring structures, played the active role in nuclei formation. 

Plot of the reciprocal of the delay time for HbS fiber formation versus the logarithm of HbS concentration. From Hofrichter et a/. with permission of the authors and publisher. 

J. Hofrichter, P. Ross W. Eaton (1974) Proc. Natl. Acad. Sci. 

One would conclude that / must approximately equal 28 for this process Hofrichter et al found a similar behavior in nucleation of human hemoglobin S (HbS) the apparent reaction order for the nucleation of HbS aggregation was about 32 (See Hemoglogin S Polymerization). Of course, such analyses are not fully justifiable, because one cannot assume ideality in the solution properties at high protein concentrations (See Molecular Crowding). 

Hagen, S. J., Hofrichter, W. A., and Eaton, W. A. 1995. Protein reaction-kinetics in a room-temperature glass. Science 269 959-62. 

Henry, E. R., and Hofrichter, J. 1992. Singular value decomposition Application to analysis of experimental data. Meth. Enzymol. 210 129-92. 

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