Hits against Receptors

Finally, how does a company select a clinical candidate that really goes to the clinic and on which they can start to spend serious money Ultimately, the demonstrated ability to go from idea to clinic is how you judge companies. 

For review on fathers of the field, see Michal Lebl s Parallel Personal Comments on Classical Papers in Comhinatorial Chemistry, J. Comb. Chem. 

Chapter 24 / Assessing Company Assets Look in theLibrary 

Receptor Size of peptide (aa) % of screened compounds 1 M or higher affinity  

What should govern corporate strategies in a fragmented market The market is by definition fragmented because no company has more than 8 to 10% of the total market. For a therapeutic area such as cardiovascular disease or oncology or psychiatry, however, there are companies that have up to 25% of the market. 

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The 3D fingerprint for the receptor is compared against the 3D fingerprint for each molecule in the Catalyst database to select the top percentage of hits. There are two possible ways of comparing 3D fingerprints ... 

Scheme 8 Hit-to-lead-focused library for early optimization against the jl opiate receptor...

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