Hitness models, risk calculation

Oncogenic Risk Calculations. On the basis of the expos ire analysis and potential oncogenic risk (oncogenic potency might be more descriptive), a risk analysis will be performed according to statistical methods like linear extrapolation (one-hit model) or multistage estimation (9.). 

ADI-type calculations were performed for noncarcinogens. For potential carcinogenic risk calculations, a linearized multistage model or a one-hit model was employed and water concentrations equivalent to calculated risks of 10"5, 10 6, and 10r were reported. No selection was made as the specific criterion however, 10-5 was suggested as a reasonable value. 

Concentration values in micrograms per liter are provided in the box on page 728 for 40 substances at the calculated 10-5 risk level at the upper bound. Both a linearized multistage model and the one-hit model (in parentheses) were used (45). Many of these values are now being updated. 

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