Historical Perspective on Pharmacogenetics

We have learned a great deal about the role of genetics in determining the safety and efficacy of drug therapy and the molecular 

In the first part of the twentieth century, reports appeared on differences among Whites, Blacks, and Chinese in response to drugs and chemicals. During the 1920s and 1930s, individual differences in sensory perception of chemicals were studied. Human family studies showed that the failure to perceive bitterness after tasting phenyl-thiourea was transmitted from parents to 

ITABLE 14.1. Some polymorphically expressed metabolic enzymes and transporters that may be amenable to genotype analysis for individualization of drug regimens 

Drng Snbstrate Implicated in Adverse Drug Reactions 

CYP2C9 2 8-20 (W) Reduced metabolism in Fluoxetine, Ibuprofen, Imipramine, 

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