Historical Nerve Agent Toxicity Studies

The UK War Office began researeh into the toxicity of the G agents, initially tabun (GA), following the capture of nerve agents from Germany in 1945. Other G agents, including sarin and soman, were tested at Porton Down in 

Nerve agent Species Route of administration LDso (mg kg i) or LCtjo (mg min m ) Lower 95% CL Upper 95% CL Siope (SE) Notes Reference o 0 1 

GB GB GB GB GB Sheep Sheep Sheep Rhesus macaque Rhesus macaque Inhalation (2 min) Inhalation (10 s) Intravenous Inhalation (1 min) Inhalation (10 s) 218 222 0.015-0.02 99 79 185 188 84 45 259 246 116 147 N/A Deaths within 24 h Deaths within 24 h Deaths within 24 h Deaths within 24 h Deaths within 24 h 82 

GD Goat Percutaneous 0.177 0.137 0.248 4.905 Depilated skin. Deaths within 48 hours 60 

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