Histoplasmosis chronic pulmonary

Patients with mild, self-limited disease, chronic disseminated disease, or chronic pulmonary histoplasmosis who have no underlying immunosuppression can usually be treated with either oral ketoconazole or IV amphotericin B. 

Chronic pulmonary histoplasmosis 0.05 Antifungal therapy generally recommended for all patients to halt further lung destruction and reduce mortality Mild-moderate disease Itraconazole 200 00 mg PO daily x 6-24 months is the treatment of choice Itraconazole and ketoconazole (200-800 mgfday orally for 1 year) are effective in 74% to 86% of cases, but relapses are common fluconazole 200-400 mg daily is less effective (64%) than ketoconazole or itraconazole, and relapses are seen in 29% of responders Severe cf/sease Amphotericin B 0.7 mg/kg/day for a minimum total dose of 35 mj kg is effective in 59% to 100% of cases and should be used in patients who require hospitalization or are unable to take itraconazole due to drug interactions, allergies, failure to absorb drug, or failure to improve clinically after a minimum of 12 weeks of itraconazole therapy... 

Histoplasmosis (capsules and injection) Treatment of histoplasmosis, including chronic cavitary pulmonary disease and disseminated, nonmeningeal histoplasmosis in nonimmunocompromised or immunocompromised patients. 

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