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Histone methyltransferases HMTs

Table 2. List of known histone methyltransferases (HMTs)... Table 2. List of known histone methyltransferases (HMTs)...
Reversible histone methylation is a highly specific process that is catalyzed by the action of histone methyltransferases (HMTs) and histone demethylases on lysine and arginine residues. Like DNMTs, HMTs employ a SAM cofactor. Lysine can be... [Pg.6]

During the past several years, a variety of crystal structures of histone lysine and arginine methyltransferase in complex with the cofactor analog SAH and/or in complex with peptide substrates have been reported [92]. However, no 3D structure of a complex between a histone methyltransferase (HMT) and an inhibitor has been reported so far. Due to the lack of experimental structures, a variety of molecular modeling and docking studies has been carried out for H MTs in order to understand the structural requirements for inhibitor binding. [Pg.74]

Histone deacetylases (HDACs), histone acetyltransferases (HMTs), histone demethylases (HDMTs), protein arginine methyltransterases (PRMTs), histone arginine demethylases (HADs), and DNA methyltransferases (DNMTs). [Pg.468]

See other pages where Histone methyltransferases HMTs is mentioned: [Pg.5]    [Pg.466]    [Pg.1728]    [Pg.257]    [Pg.173]    [Pg.64]    [Pg.5]    [Pg.466]    [Pg.1728]    [Pg.257]    [Pg.173]    [Pg.64]    [Pg.351]    [Pg.301]    [Pg.466]    [Pg.213]    [Pg.259]    [Pg.3438]    [Pg.102]    [Pg.7]    [Pg.38]    [Pg.214]   
See also in sourсe #XX -- [ Pg.153 ]



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