Histone cross- talk

Figure 1.4 Example of histone cross-talk on histone H3. PRMT6 and the ASH2/WDR5/MLL complex are capable of methylation of H3R2 and H3K4, respectively (a). PRMT6 cannot methylate R2 in the presence of H3K4 trimethylation (b). Asymmetric dimethylation of R2 prevents...

Figure 3. Histone modification cross-talk between histone H2A phosphorylation on T119 and another histones methylation or acetylation in nhk-1 mutants (a) Histone H3 (K14) and (b) Histone H4 (K5) are not acetylated in the nhk-1 mutant, (c) Histone H4 (K12) is acetylated in the nhk-1 mutant (Ivanovska et al. 2005). Phosphorylation is represented by the blue flag, and acetylation is represented by the black flag...

Daujat, S., Bauer, U-M., Shah, V., Turner, B.M., Berger, S., and Kouzarides, T. (2002) Cross-talk between CARMl methylation and CBP acetylation on histone H3. Curr. Biol., in press. 

In fact, the cross-talk between histone methylation and DNA methylation has been experimentally demonstrated for the first time in Neurospora [145] (see commentary by Bird [146]) and proved the second scenario. Using the power of Neurospora genetics, Tamaru and Selker [145] have identified a gene which, when mutated, abolishes methylation of all tested DNA sequences. This gene, dim-5, is different from dim-2, the previously identified gene that encodes the only DNA methyltransferase in Neurospora responsible for all known cytosine methylation in this fungus. The dim-5 gene encodes a histone H3 methyltransferase the deduced polypeptide sequence contains a SET domain with sequence similarity to some known histone methyltransferases moreover, the recombinant DIM-5 protein exhibits histone methyltransferase activity in vitro. Additional in vivo experiments... 

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