Histology protective role

It seemed also (de Weck and Brun, 1957) that the course of the reaction was slightly modified by the acanthosis. After 24 hours the lesions on the acanthotic nipples were clearly less significant. Nonetheless, the histological differences observed between the reactions on the flanks and nipples with or without acanthosis do not permit us to affirm that acanthosis plays a protective role against the triggering of an eczematous reaction in animals sensitized with DNCB. . . . But we should keep in mind that under certain conditions, acanthosis can have a protective effect relative to the primary toxic reaction (see p. 8). 

Monosubstituted Mn(ii)-based complexes, which catalyze the dismutation of superoxide as shown by stopped-flow kinetic analysis, were tested for antiinflammatory activity in the mouse acetic acid-induced colitis model. As can be seen from Table 3, all of the SOD mimics are anti-inflammatory. Histological analysis of the colonic tissue confirmed these results. Of particular importance is the observation that Mn(ii) complexes that have no SOD activity, specifically the Mn(ii) dichloro complexes of 1,4,7,10,13-pentaazacyclohexadecane and 1,4,7,11,14-pentaazacycloheptadecane, do not protect against the colonic inflammation induced by acetic acid when the compounds are administered in-tracolonically at a dose of 30mgkg These results are consistent with a role for superoxide as a mediator of neutrophil-dependent inflammation. Consistent with this hypothesis is the observation that SC-52608 inhibits neutrophil-dependent inflammation induced by the intradermal administration of leukotriene 64, a neutrophil chemoattractant. ... 

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