Histidine acid phosphatase family

The glucose-l-phosphatase from E. coli hydrolyzes phytate as well as glucose-1-phosphate. This enzyme is a member of the histidine acid phosphatase family (Lee et al., 2003). Glucose-l-phosphatase cleaves only the 3-phosphate from phytate, and no further hydrolysis takes place. It is the only phosphatase... 

Two classes of enzymes that degrade myoinositol hexakisphosphate are recognized 3-phytase (EC 3.1.3.8) initially cleaves the phosphate at the 3-position on the myoinositol ring, leaving myo-inositol 1,2,4,5,6 pentakisphosphate (this phytase belongs to the family of histidine acid phosphatases Mitchell et al, 1997), whereas 6-phytase (EC 3.1.3.26) preferentially initiates dephosphorylation at the 6-position, leaving myoinositol 1,2,3,4,5 pentakisphosphate. 

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