Hippocampus methamphetamine

Commins et al. (1987) have also reported the formation of 5,6-dihydroxy-tryptamine in rat hippocampus after a single, high doses of methamphetamine. They suggested that the formahon of 5,6-dihydroxytryptamine, a known neurotoxie substance, may mediate the neurotoxie effects of methamphetamine toward serotonergic nerve terminals. 

Rocher, C., Gardier, A.M. Effects of repeated systemic administration of d-fenflur amine on serotonin and glutamate release in rat ventral hippocampus comparison with methamphetamine using in vivo microdialysis. Naunyn Schmiedeberg s Arch. Pharmacol. 363 422, 2001. 

Kuczenski, R., Segal, D.S., Cho, A.K., Melega, W. Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methamphetamine. J. Neurosci. 15 1308, 1995. 

The deficits in TPH activity and content of 5-HT and 5-HIAA normally seen in MDMA-treated rats were attenuated by concurrent administration of MT these deficits returned when L-dopa was administered concurrently with MT and MDMA. Prior treatment with 6-OHDA (described above) selectively attenuated the serotonergic deficits in the neostriatum while no protection by 6-OHDA occurred in the hippocampus or cerebral cortex. Prior depletion of DA with reserpine attenuated the neurotoxicity of MDMA. From these experiments the authors concluded that DA and/or its metabolites play a key role not only in the neurotoxicity observed with methamphetamine, but also with its methylenedioxy analogs. 

Bowyer, J.R, Ali, S., 2006. High doses of methamphetamine that cause disruption of the blood-brain barrier in limbic regions produce extensive neuronal degeneration in mouse hippocampus. Synapse 60,521-532. 

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