Hintonia latiflora

Korec R, Sensch KH, Zoukas T. (2000) Effects of the neoflavonoid coutareagenin, one of the antidiabetic active substances of Hintonia latiflora, on streptozotocin-induced diabetes mellitus in rats. Arzneimittelforschung 50 122-128. 

Asperula odorata (sweet woodruff) Cephaelis ipecacuanha (ipecac) Hintonia latiflora (copalchi bark) Morinda citrifolia (non )... 

Viscum album (mistietoe) Viscaceae (Christmas Copalchi bark Hintonia latiflora... 

Hintonia latiflora (copalchi bark) has been advocated as a hypoglycemic agent, an effect that has been attributed to the neoflavonoid coutareagenin (1). Its use has been associated with liver toxicity but a causal relation could not be established (2). 

Two natural antiparasitic coumarins, 5-0-p-D-glucopyranosyl-7,4 -dimethoxy-3 -hydroxy-4-phenylcoumarin and 5-0-P-D-glucopyranosyl-7-methoxy-3, 4 -dihydroxy-4-phenylcoumarin (Fig. 2) isolated from Hintonia latiflora stem bark, have been reported to exhibit antimalarial activity against the development of Plasmodium berghei schizonts in vitro, the second one also showing significant activity in vivo [79]. 

Reguero, M. T., R. Mata, R. Bye, E. Linares, and G. Delgado, Chemical studies on Mexican plants used in traditional medicine. II. Cucurbitacins from Hintonia latiflora, J. Nat. Prod., 50. 315-316 (1987). 

---