High Resolution Accurate Mass MID Data Acquisition

3 High Resolution Accurate Mass MID Data Acquisition 

Target compound analysis using high mass resolution, for example, for PCDD/ PCDFs, pesticides, POPs or pharmaceutical residues are typically performed by monitoring the compound-specific accurate mass ions at the expected retention time for each analyte. High resolution GC-MS target compound applications benefit from a unique technical feature referred to as the lock-mass technique for performing MID analyses. The lock mass technique provides ease of use, combined with a maximum quantitative precision and certainty in analyte confirmation. 

For MID data acquisition, the fixed magnet setting with a variable acceleration voltage is typically used. The mass calibration for MID data acquisition follows a special procedure during the data acquisition in the form of a scan inherent mass calibration. This internal mass cahbration is performed during MID analysis in every scan before acquisition of the target compound intensities. Most recent 

The internal mass calibration process is performed by the instrument control in the background without being noticed by the operator. In particular, it provides superior stability especially for high sample throughput with extended runtimes. 

A reference compound is leaked continuously from the reference inlet system during the GC run into the ion source. Typically perfluoro-tributylamine (FC43) is used as reference compound in HRGC-HRMS for dioxin analysis. Other reference compounds may be used to suit individual experimental conditions. 

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