High melting point drug

KinetiSol Processing of High-Melting-Point Drugs... 

Unlike other polymers such as polyethylene glycol, melted povidone is almost not used as an embedding matrix for drugs, except in melt extrusion, because of its high melting point (over r8o °C with decomposition). 

In topical formulations, where the dmg is occasionally formulated as a suspension of solid particles, a relatively high melting point and absence of polymorphic transitions of the salt are essential requirements. This is important because the majority of creams and ointments are prepared by warming the oil phase or ointment base during incorporation of the drug substance into the formulation. 

The discussions of pK, log P, and log D above all pertain to the end point analysis of the solubility of a drug candidate. A correlation exists between log P of neutral immiscible liquids with their solubility in water however, for solids solubility also depends on the energy required to break the crystal lattice where log P is related to solubility. It is therefore possible to have compounds with high log P values, which are stiU soluble on account of their low melting point. Similarly, it is possible to have a low log P compound with a high melting point, which is very insoluble. 

Amine salts have physical properties characteristic of other ionic compounds. They are white crystalline solids with high melting points. Because they are ionic, amine salts are more soluble in water than the parent amines. For this reason, amine drugs... 

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