High-mannose oligosaccharides formation

Notes and discussion. Exploiting different reactivity levels, Ley et al. succeeded not only in synthesizing the title trisaccharide 48 in high yield, but could also further elaborate the anomeric reactivity to form the corresponding tetrasaccharide 50 and a high-mannose type nonasaccharide [40, 41]. Similar approaches led first to the formation of key intermediates of other oligosaccharides, e.g. a GPI anchor, and finally to the natural product itself [43, 56]. 

Figure 2. Structure of human thyro-globulin and its degradation in thyroid lysosomes. A single thyroglobulin molecule is depicted schematically with positions of its iV-linked oligosaccharides [41] , complex o high-mannose , complex or high-mannose , hybrid or complex. Tyrosines Y5 and Y130 are the major residues involved in the formation of hormones T4 and T3 [1]. Principal sites of proteolytic cleavage by lysosomal cathepsins B, D, and L are shown as vertical lines [3],...

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