Hierarchies of Mammalian NER Recognition Signals

The sequence-dependent trend is conserved in the prokaryotic UvrABC system, in which the NER dual-incision efficiency is around 2.4-fold higher for the same 10S (+)-trans-anti-B[a]P-N2-dG adduct in the TG T case than the CG C-II case [124]. Similarly, the G6 G7 duplex is incised more efficiently by a factor of around 

Sequence/adduct Conformation Prominent Watson-Crick hydrogen-bonding disturbance Bend Minor groove width 

G6 G7 (+)-tvans- minor groove [79] destabilized base pair 5 -flanking G [47, 79] rigid [78] enlarged [47, 79] 

TG T (+)-truns- heterogeneous minor groove [127] partially destabilized base pair 5 -flanking G [26,127] flexible [82,127] enlarged [26] 

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