Hexitol nucleic acids

The hybridisation properties of various 6-membered nucleic acid derivatives with complementary RNA have been studied. The 6-membered nucleic acid derivatives studied are a- or P-hexitol nucleic acid, HNA, cyclohexene nucleic acid, CeNA, (55), cyclohexane nucleic acid, CNA, and a- or p-homo-DNA, (56-58). Considerable cross-pairing of the nucleic acid derivatives was observed, and apart from p-homo-DNA, all analogues bound to RNA with generally greater stability than RNA RNA in a polyAipolyT duplex. The most stable duplex was p-HNA p HNA. 

There has been a further report on altritol nucleic acids (ANA, 258) (see Vol. 33, p. 316), which notes that they are superior to the corresponding DNA, RNA or hexitol nucleic acids (as 258, but lacking the hydroxy groups) in supporting efficient non-enzymatic template-directed synthesis of complementary RNAs from nucleoside 5 -phosphoro-2-methylimidazolides ... 

Barker, G. R., Nucleic Acids, XI, 285-333 Barker, S. A., and Bourne, E. J, Acetals and Ketals of the Tetritols, Pentitols and Hexitols, VII, 137-207 Barrett, Elliott P, Trends in the Development of Granular Adsorbents for Sugar Refining, VI, 205-230 Barry, C. P., and Honeyman, John, Fructose and its Derivatives, VII, 53-98... 

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