Altritol nucleic acid

A number of references to the incorporation of modified nucleosides into oligonucleotides are given elsewhere in this chapter, and some relevant chemistry of protecting groups in discussed in Section 15. A reference to altritol nucleic acids is mentioned in Section 16. 

There has been a further report on altritol nucleic acids (ANA, 258) (see Vol. 33, p. 316), which notes that they are superior to the corresponding DNA, RNA or hexitol nucleic acids (as 258, but lacking the hydroxy groups) in supporting efficient non-enzymatic template-directed synthesis of complementary RNAs from nucleoside 5 -phosphoro-2-methylimidazolides ... 

A few hexose-based sugar modifications have been applied to oligonucleotides. 2 -Fluoro cyclohexenyl nucleic acids (CeNA) (24) have been incorporated into a DNA duplex where it was slightly destabilising but exhibited enhanced nuclease stability.A ciystal structure of RNA with (24) showed that it formed an A-type duplex not unlike that found with RNA RNA duplexes. A crystal structure of a duplex between RNA and altritol nucleic acids (25) has been reported and the hybrid structure formed an A-type helix analogous to a fully RNA duplex. Aptamers have... 

Fisher M., Abramov M., Van Aerschot A., Xu D., Juliano R.L., Herdewijn P. (2007) Inhibition of MDR1 expression with altritol-modified siRNAs. Nucleic Acids Res, 35(4) 1064-74. 

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