Hexaaza-cyclophane

Isophthaldialdehyde cyclocondensed with l,5-diamino-3-azapentane followed by reduction to give the 2 2 hexaaza-cyclophane product (Menif and... 

To the date, the studies reviewed here about hexaaza-cyclophane systems have been focused in mechanistic aspects. These studies demonstrate that the nature of the interaction between the CO2 molecule and the complexes depends on the metal and on the ligand contrarily to that observed for cyclam systems (see the next section). However, all this information is still not enough to fully understand the relevant steps in the formation or in the kinds of intermediates in order to design a more catalytic and selective complex based on these systems. Also, it is necessary to improve the synthetic approach of these systems with different substituents in order to gain systematic knowledge about the new structures and the understanding of its chemical nature and kind of products obtained in each case. In this way, a feedback between the experimental and theoretical data will be possible and therefore a more efficient system for the target molecule. 

Figure 14.21. Molecular structure and atoms numbering of the hexaaza-cyclophane Cu(II) complex. Reprinted by permission of Elsevier B.V.

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