Hevein-like domain

Karisola, P, Kotovuori, A., Poikonen, S. et al. 2005. Isolated hevein-like domains, but not 31-kd endochitinases, are responsible for IgE-mediated in vitro and in vivo reactions in latex-fruit syndrome. J Allergy Clin Immunol 115 598-605. 

As a typical example, ITC data on UDA, which contains two hevein-like domains per monomer with two non-identical-interacting sites (one for each... 

C. Blanco, Latex-fruit syndrome, Curr. Allergy Asthma Rep., 3 (2003) 47-53 A. Diaz-Perales, C. Collada, C. Blanco, R. Sanchez-Monge, T. Carrillo, C. Aragoncillo, and G. Salcedo, Class I chitinases with hevein-like domain, but not class II enzymes, are relevant chestnut and avocado allergens, J. Allergy Clin. Immunol, 102 (1998) 127-133. 

Individuals with latex protein allergy often exhibit reactions to plant-derived food and fresh fruits, such as avocado or banana, too. N-terminal hevein-like domains seem to be responsible for these mediated reactions in the so-called latex-fruit syndrome [12]. 

Besides these hevein-like domains, lipid transfer proteins (LTPs) play an important role in food allergy [13-15] and they have therefore been suggested as model plant food allergens. Only recently, the first citric LTPs were isolated from oranges and lemons with molecular masses of 9610 and 9618 Da, respectively, determined by MALDI-TOF-MS [16]. LTPs have also been identified as the major apricot allergens [17]. The molecular masses of the intact proteins were deduced... 

PR protein P2 (no hevein-like N-terminal CBD) (protein) (tomato) (Solanaceae) induced Hevein, Nicotiana PR-4 Solanum Win C-terminal domains homologous]... 

Sambucus CBP SN-HLPf (hevein-like N-terminal domain Class V chitinase-like C-terminal domain) Sambucus nigra (elderberry) (Caprifoliaceae) [fruit] Chitin... 

Mikkola, J.H., Alenius, H., Kalkkinen, N., Tuijanmaa, K., Palosuo, T. and Reunala, T., Hevein-like protein domains as a possible cause for allergen cross-reactivity between latex and banana. J. Allergy Clin. Immunol., 102, 1005-1012 (1998). 

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