Heteroreceptors in disease

Serotonin 5-HT1A Human cDNA Alzheimer s disease, anxiety, depression, schizophrenia, hypertension, inflammation, pain, migraine, spasticity ulcers, obesity glaucoma Somatodendritic autoreceptor in hippocampus and raphe nuclei, circadian rhythm, somatodendritic heteroreceptor at cholinergic terminals of myenteric plexus... 

Dopamine autoreceptors play a role in Parkinson s disease, schizophrenia and drug addiction. Dopamine heteroreceptors affecting the release of acetylcholine and of amino acid neurotransmitters in the basal ganglia are also relevant for Parkinson s disease. Peripheral dopamine heteroreceptors on postganglionic sympathetic terminals influence heart rate and vascular resistance through modulation of noradrenaline release. 

Both the histamine neuron innervation and the density of H3 receptors are increased in the substantia nigra of Parkinsonian patients (Anichtchik et al. 2000 2001). The receptors probably are the H3 heteroreceptors on striato-nigral GABA terminals, and their increase may contribute to the depression of GABA release in the substantia nigra in Parkinson s disease (Garcia-Ramirez et al. 2004). 

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