Heteronuclear multiple-quantum correlation combination experiments

The addition of a HOHAHA mixing step to a heteronuclear multiple-quantum correlation (HMQC) experiment (Bax et al., 1983) yields two-dimensional HMQC-HOHAHA experiments (Lerner and Bax, 1986 Davis, 1989b Oh et al., 1989 Gronenborn et al., 1989b John et al., 1991 Willker et al., 1993a). Domke and McIntyre (1992) combined heteronuclear Hartmann-Hahn transfer with multiplicity editing techniques. 

HSQC) or heteronuclear multiple quantum correlation (HMQC). The combined experiments such as 2D HSQC(HMQC)-TOCSY experiments are powerful tools for the assignment of the 13C and 11 resonances belonging to the same sugar residue providing enhanced dispersion of TOCSY correlations in the carbon dimension. More recendy, different carbon multiplicity editing methods, for example, DEPT (distortionless enhanced polarization transfer)-HMQC and E-HSQC, have been developed to reduce the complexity of proton-carbon correlation spectra and to enhance the resolution by narrowing the applied spectral window.11... 

HMQC sequences can be combined with DEPT editing, allowing for the editing of multiplicities in heteronuclear correlations. The resulting experiments, such as HDQC (heteronuclear double quantum correlation), HTQC (heteronuclear triple quantum correlation) and HQQC (heteronuclear... 

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