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Heterocyclic cyanides

The complexers maybe tartrate, ethylenediaminetetraacetic acid (EDTA), tetrakis(2-hydroxypropyl)ethylenediamine, nittilotriacetic acid (NTA), or some other strong chelate. Numerous proprietary stabilizers, eg, sulfur compounds, nitrogen heterocycles, and cyanides (qv) are used (2,44). These formulated baths differ ia deposition rate, ease of waste treatment, stabiHty, bath life, copper color and ductiHty, operating temperature, and component concentration. Most have been developed for specific processes all deposit nearly pure copper metal. [Pg.112]

This procedure is representative of a new general method for the preparation of noncyclic acyloins by thiazol ium-catalyzed dimerization of aldehydes in the presence of weak bases (Table I). The advantages of this method over the classical reductive coupling of esters or the modern variation in which the intermediate enediolate is trapped by silylation, are the simplicity of the procedure, the inexpensive materials used, and the purity of the products obtained. For volatile aldehydes such as acetaldehyde and propionaldehyde the reaction Is conducted without solvent in a small, heated autoclave. With the exception of furoin the preparation of benzoins from aromatic aldehydes is best carried out with a different thiazolium catalyst bearing an N-methyl or N-ethyl substituent, instead of the N-benzyl group. Benzoins have usually been prepared by cyanide-catalyzed condensation of aromatic and heterocyclic aldehydes.Unsymnetrical acyloins may be obtained by thiazol1um-catalyzed cross-condensation of two different aldehydes. -1 The thiazolium ion-catalyzed cyclization of 1,5-dialdehydes to cyclic acyloins has been reported. [Pg.173]

The reaction of tnfluoromethyl-substituted A -acyl umnes toward nucleophiles in many aspects parallels that of the parent polyfluoro ketones Heteronucleophiles and carbon nucleophiles, such as enarmnes [37, 38], enol ethers [38, 39, 40], hydrogen cyanide [34], tnmethylsilylcarbomlnle [2,47], alkynes [42], electron-nch heterocycles [43], 1,3-dicarbonyl compounds [44], organolithium compounds [45, 46, 47, 48], and Gngnard compounds [49,50], readily undergo hydroxyalkylation with hexafluoroace-tone and amidoalkylation with acyl imines denved from hexafluoroacetone... [Pg.842]

Thiophenealdehydes have been condensed with aliphatic aldehydes, methyl ketones,cyclic ketones, " benzyl cyanides,and aliphatic nitro compounds to the corresponding vinylthiophenes. By the use of potassium methylate, 2-thiophenealdehyde has been condensed with the reactive methyl groups of iV-heterocyclic compounds. Thiophenealdehydes have... [Pg.94]

There are a few scattered references to the reaction of nonphenohc six-membered heterocyclics with dichlorocarbene under Reimer-Tiemann conditions. Thus a mixture of 2-methylpyridine, chloroform, and sodium hydroxide is reported to contain sorbic acid and cyanide ions after standing for several months. Another similar reaction of... [Pg.76]

Heterocyclic structures analogous to the intermediate complex result from azinium derivatives and amines, hydroxide or alkoxides, or Grignard reagents from quinazoline and orgahometallics, cyanide, bisulfite, etc. from various heterocycles with amide ion, metal hydrides,or lithium alkyls from A-acylazinium compounds and cyanide ion (Reissert compounds) many other examples are known. Factors favorable to nucleophilic addition rather than substitution reactions have been discussed by Albert, who has studied examples of easy covalent hydration of heterocycles. [Pg.171]

The y-keto nitriles shown in Table I were prepared by the cyanide-catalyzed procedure described here. This procedure is generally applicable to the synthesis of y-diketones, y-keto esters, and other y-keto nitriles. However, the addition of 2-furancarboxaldehyde is more difficult, and a somewhat modified procedure should be employed. Although the cyanide-catalyzed reaction is generally limited to aromatic and heterocyclic aldehydes, the addition of aliphatic aldehydes to various Michael acceptors may be accomplished in the presence of thioazolium ions, which are also effective catalysts for the additions. [Pg.165]

Reactions of Heterocyclic N-Oxides with Trimethylsilyl Cyanide, Trimethylsilyl Azide, Trimethylsilyl Isothiocyanate, and Trimethylsilyl Halides... [Pg.147]

Heterocyclic N-oxides such as pyridine, quinoline, or isoquinoline N-oxides can be converted into a mixture of 2- and some 4-cyanopyridines, 2- or 4-cyanoquino-lines, or 1-cyanoisoquinolines, in 40-70% yield, in a Reissert-Henze reaction, by activation of the N-oxide function by O-acylation [1] or O-alkylation [2, 3] followed by treatment with aqueous alkali metal cyanide in H2O or dioxane. [Pg.147]

Alternatively, unreactive heterocyclic N-oxides might also be readily converted into their a-cyano heterocycles on reaction with the strongly electrophilic Cl3SiCN, Cl2Si(CN)2, or ClSi(CN)3, which should be formed in situ on addition of SiCl4 to a solution or suspension of sodium or potassium cyanide in acetonitrile or DMF (cf the analogous formation of ClSi(N3)3 708 in Scheme 5.70). [Pg.152]

Many companies spiecialize in the production of chemicals grouped in chemical trees characterized by the same chemical roots (compounds) or the same/similar method of manufacturing. Examples are the Lonza trees based upon (I) hydrogen cyanide, (2) ketene (H2C=C=0) and diketene (4-methyleneoxetan-2-one), and (3) nitrogen heterocycles. A different t3q)e of tree is that of DSM Chemie Linz, which branches out from ozonolysis as the core technology (Stinson, 1996). Wacker Chemie has developed its chemical tree leading to acetoacetates, other acylacetates, and 2-ketones (Stinson, 1997). Table 1.1 shows examples of fine chemicals. [Pg.3]

The formation of colored materials from leuco bases such as 4 and 5 is accomplished by treatment with acids such as acid clay, bisphenol A, acetic acid, or silica gel.39 For leuco base 4 the leaving group is hydroxy, alkoxy, or cyanide, or a nitrogen-containing heterocycle. [Pg.131]

The wide latitude of structural variation consistent with bioactivity in this series is illustrated by the observation that antiinflammatory activity is maintained even when the second aromatic group is attached directly to the pyrrole nitrogen rather than to the heterocyclic ring via a carbonyl group as in the previous case. Condensation of p-chloroaniline with hexane-2,5-dione (or its dimethoxy-tetrahydrofuran equivalent) affords pyrrole 7. The acetic acid side chain is then elaborated as above. Thus, Mannich reaction leads to the dimethylaminomethyl derivative 8, which is in turn methylated (9) the quaternary nitrogen replaced by cyanide to afford 10. Hydrolysis of the nitrile then gives clopirac (11). [Pg.234]

In other words, a synthetic route to polypeptides which requires only HCN and water is presented preformed a-amino acids are not necessary. According to Matthews, the pyrolysis of cyanide polymers can give nitrogen-containing heterocycles with purine and pyrimidine structures in other words, the HCN world ... [Pg.106]


See other pages where Heterocyclic cyanides is mentioned: [Pg.312]    [Pg.758]    [Pg.48]    [Pg.312]    [Pg.758]    [Pg.48]    [Pg.113]    [Pg.123]    [Pg.294]    [Pg.400]    [Pg.206]    [Pg.15]    [Pg.57]    [Pg.209]    [Pg.210]    [Pg.215]    [Pg.217]    [Pg.217]    [Pg.217]    [Pg.217]    [Pg.217]    [Pg.419]    [Pg.149]    [Pg.150]    [Pg.151]    [Pg.284]    [Pg.29]    [Pg.13]   
See also in sourсe #XX -- [ Pg.345 ]




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Hydrogen cyanide derivatives, synthesis heterocycles from

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