Heteroaromatic compounds homolytic substitution

Thus the overall picture of homolytic substitution of heteroaromatic compounds has undergone only minor modification as regards arylation, but very great modification as regards substitution with nucleophilic radicals, since Norman and Radda reviewed the field in these Advances. 

This awareness in a short time led to new homolytic aromatic substitutions, characterized by high selectivity and versatility. Further developments along these lines can be expected, especially as regards reactions of nucleophilic radicals with protonated heteroaromatic bases, owing to the intrinsic interest of these reactions and to the fact that classical direct ionic substitution (electrophilic and nucleophilic) has several limitations in this class of compound and does not always offer alternative synthetic solutions. Homolytic substitution in heterocyclic compounds can no longer be considered the Cinderella of substitution reactions. 

Advances in Homolytic Substitution of Heteroaromatic Compounds F. Minsci and O. 

Homolytic Substitution Reactions of Heteroaromatic Compounds in Solution K. C. Bass and P. Nababsing, Adv. Free-Radical Chem., 1972, 4, 1-48. 

Homolytic substitution of thiophene as well as homolytic aromatic substitutions by thienyl radicals has been reviewed (73IJS295). In addition to this, a wider review on homolytic substitution of heteroaromatic compounds (74AHC(16)123) also briefly covers work done in the area of thiophenes. 

Homolytic substitution of heteroaromatic compounds, 16, 123 Hydantoins, chemistry of, 38, 177 Hydrogen cyanide derivatives, synthesis of heterocycles from, 41, 1 Hydrogen exchange base-catalyzed, 16, 1 one-step (labeling) methods, 15, 137 Hydrogenated porphyrin derivatives hydroporphyrins, 43, 73 Hydroxamic acids, cyclic, 10, 199 1 -Hydroxyindoles, 1 -hydroxytryptophans, and 1-hydroxytryptamines,... 

Heteroaromatic compounds free-radical substitutions of, 2, 131 homolytic substitution of, 16, 123 nitrogen, covalent hydration in, 4, 1, 43 prototropic tautomerism of. 1, 311,339 2, I, 27 SI... 

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