Hereditary persistence of fetal hemoglobin

Mediterranean, a-thalassemia and hemoglobin C in Africa, and hereditary persistence of fetal hemoglobin in North Africa and India. These combinations have created diverse presentations of this disease, the most severe being hemoglobin SS and hemoglobin S(3 zero thalassemia. 

Patients who have hemoglobin SS as well as a mutation that produces hereditary persistence of fetal hemoglobin have few... 

Heterogeneity of Hb-F in the Hereditary Persistence of Fetal Hemoglobin (HPFH)... 

F7. Fessas, P., and Stamatoyaimopoulos, G., Hereditary persistence of fetal hemoglobin in Greece. A study and a comparison. Blood 24, 223-240 (1964). 

Shelton, J. R., Shelton, J. B., and Apell, G., Nature of fetal hemoglobin in the Greek type of hereditary persistence of fetal hemoglobin with and without concurrent -thalassemia. J. Clin. Invest. 49, 1035-1040 (1970). 

An algorithm based on the MCV, MCH, Hb A2, and Hb F quantifications has been advocated to better discriminate between P-thalassemia minor, iron deficiency, 6P"thalassemia, and hereditary persistence of fetal hemoglobin (HPFH). ... 

Conley CL, Weatherall DJ, Richardson SN, Shepard MK, Charache S. 1963. Hereditary persistence of fetal hemoglobin A study of 79 affected persons in 13 Negro families in Baltimore. Blood 21 261-281. 

Herman EC Jr, Conley CL. 1960. Hereditary persistence of fetal hemoglobin. A family study. Am J Med 29 9-17. 

VI. HEMOGLOBINOPATHIES, HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN, AND HEMOGLOBIN SWITCHING... 

Fig. 44.19. The 7-globin gene promoter indicating some of the transcription factor binding sites associated with hereditary persistence of fetal hemoglobin.

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