Imidazole, heptafluorobutyryl

Procedures based on GC/MS for the determination of the lewisite 1 decomposition product 2-chlorovinylarsonous acid (CVAA, CAS number 85090-33-1) in urine and blood have also been developed. In one procedure, CVAA is converted with BAL the resulting CVAA/BAL product isolated by SPE on a C18-cartridge and further derivatized with heptafluorobutyryl imidazole (51). A later developed procedure is based on the derivatization of CVAA with 1,3-propanedithiol followed by SPME isolation and GC/MS analysis. Using SIM at the molecular ion peaks, the limit of detection was determined at 7.4 pg per ml urine (52). 

Use. For glpc separation of catecholamines. Horning et at.1 converted these substances first into the trimethylsilyl ethers by reaction with trimethylsilyl-imidazole in acetonitrile acylation of primary and secondary groups was then effected by addition of N-heptafluorobutyrylimidazole. The resulting trimethylsilyl ether-heptafluorobutyryl (TMSi-HFB) derivatives were found to have excellent glpc properties.1... 

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