Hepatoportal sclerosis

Toxically induced hepatoportal sclerosis/periportal fibrosis... 

Various infectious, toxic or immunological lesions lead to a presinusoidal block in adults. From a primary endothelial lesion, endophlebitis ensues. Rich in fibres and deficient in cells, it is ultimately responsible for the obliteration and even disappearance of the portal branches. Obliterative portal venopathy (N.C. Nayak et al., 1969) with portal and periportal fibrosis and subsequent perisinusoidal sclerosis is referred to as hepatoportal sclerosis (W P. Mikkelsen et al., 1965). This is a complex disorder involving splenomegaly, hypersplenism and portal hypertension, which has also been described as non-cirrhotic portal fibrosis (XL. Boyer et al., 1967) or idiopathic portal hypertension (K. Okuda et al., 1982). (I2l, 127) Band s syndrome (7) probably fell into this group ... 

Other hepatic responses that can be occupationally related include steatosis, cholestatic injury, hepatoportal sclerosis, and hepatic porphyria. The acute care provider should always consider a toxic chemical etiology in the differential diagnosis of liver disease. 

A case report described mercaptopurine-induced hepatoportal sclerosis leading to non-cirrhotic portal hypertension in a patient with Crohn disease [76 ]. 

Tuyama AC, Krakauer M, Alzaabi M, Fiel MI, Legnani P, Schiano TD. Mercaptopurine-induced hepatoportal sclerosis in a patient with Crohn s disease. J Crohns Colitis August 2013 7(7) 590-3. PubMed PMID 22841133. Epub 2012/07/31. eng. 

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