Hepatocytes gap junctions

Heptachlor, chlordane, and endosulfan (another cyclodiene pesticide) were shown to inhibit hepatocyte gap junctional intercellular communication (Ruch et al. 1990). All three pesticides showed similar dose-response relationships. Further testing with chlordane and heptachlor indicated that inhibition of the cytochrome P-450 system had no effect on this response. These results suggest that the interference with intercellular communication is not directly tied into the effects of these cyclodienes on the P-450 system. 

Ruch RJ, Fransson R, Flodstrom S, etal. 1990. Inhibition of hepatocyte gap junctional intercellular communication by endosulfan, chlordane, and heptachlor. Carcinogenesis 11 (7) 1097-1102. 

Saez JC, Naim AC, Czemick A, Spray DC, Hertzberg EL, Greengard P, Bennett MVL Phosphorylation of connexin 32, the hepatocyte gap junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca/calmoduUn-dependent protein kinase II. Eur J Biochem 1990 192 263-273. 

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