Hepatitis variants

Intermediate hepatic variants with juvenile onset exist a rare fatal neuromuscular form has been described. 

Le PS, Kang H, Harris SF, Leveque V, Giannetti AM, Ali S, Jiang WR, Rajyaguru S, Tavares G, Oshiro C, Hendricks T, Klumpp K, Symons J, Browner ME, Cammack N, Najera I (2006b) Selection and characterization of repUcon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus, J Virol 80 6146-6154... 

A common hepatic lipase gene promoter variant determines clinical response to intensive lipid lowering treatment. Atherosclerosis 2000 151 266. 

Hong SP, Kim NK, Hwang SG, Chung HJ, Kim S, et al. 2004. Detection of hepatitis B virus YMDD variants using mass spectrometric analysis of oligonucleotide fragments. J Hepatol 40 837. 

There are four variants of the Grinization Mix and the Grinization Pro use for patients with chronic viral hepatitis C during antiviral therapy realization. 

Vasospastic angina (Prinzmetal s variant), unstable (crescendo or preinfarction) angina, chronic stable (effort-associated) angina PO Initially, 80-120 mg 3 times a day For elderly patients and those with hepatic dysfunction, 40 mg 3 times a day. Titrate to optimal dose. Maintenance 240-480 mg/day in 3-4 divided doses. 

More than 24 human genes code for 16 variants of IFN-a molecules. Human IFN-a proteins contain either 165 or 166 amino acid residues, with an overall molecular weight of 19,000 Da. The two primary human subtypes are IFN-a-2a and IFN-a-2b, which differ only at position 23 (a lysine residue in IFN-a-2a and arginine in IFN-a-2b). IFN-a type proteins exhibit complex antineoplastic and antiviral properties. Recombinant variants have been studied in the treatment of hepatitis C. 

Some people with elevated lipoprotein levels have VLDL that migrates on electrophoresis in the (3 band rather than the pre-(3 band (see Box 2-A). The presence of the (3-VLDL is associated with a high incidence of artery disease,218 which is most likely to develop in persons homozygous for a genetic variant of apolipoprotein E. The problem may arise because apo-E is required for receptor-mediated uptake of VLDL, which interacts both with tissue LDL receptors and with hepatic apo-E receptors. Genes for many of the... 

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