Hepatitis general approach

The micelle formulation approach often possesses disadvantages such as its toxicity associated with surfactants even at relatively low concentrations. In general, nonionic surfactants have the least toxic effects. Cremophor EL produces hypersensitivity reactions in human and animals (Jonkman-de Vries et al., 1996). Tween-80 is also believed to cause acute hepatitis and renal failure (Uchegbu and Florence, 1996). On intravenous administration, owing to their surface activity, surfactant molecules have the potential to penetrate and disrupt biological membranes and can be hemolytic (Ten Tije et al., 2003). Often the absorption capacity of the micelle is too small and the extent of the... 

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