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Heparinized surfaces, coagulation factors

There are various inhibitors within the coagulation system that counterregulate activation of the coagulation cascade. Among them, antithrombin III (AT-III) and protein C (PC) are the most important (SI). AT-III binds in the presence of heparin the activated factors F-IXa, F-Xa, and F-IIa (thrombin). PC is activated by a complex formed between thrombin and thrombomodulin, a surface protein of endothelial cells. Once activated, PC in the presence of protein S (PS) specifically degrades activated factors F-Va and F-VIIIa. PC decreases in the course of sepsis in relation to the severity of the condition (L15). Experimental studies have... [Pg.77]

Blezer R, Cahalan I, Cahalan PT et al. Heparin coating oftanta-lum coronary stents reduces surface thrombin generation but not factor Ixa generation. Blood Coagul Fibrinolysis 1998 9(5) 435-440. [Pg.261]

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See also in sourсe #XX -- [ Pg.174 ]



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Coagulation factors

Coagulation surface

Heparin surface

Heparinized surfaces

Surface factor

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