Heparin oxidative hydrolysis

Wolfrom and Rice hydrolyzed heparin in the presence of bromine in order to convert the uronic acids released into aldaric acids.24 The same method, oxidative hydrolysis, was used by Rees and coworkers in order to protect liberated 3,6-anhydrohexose residues. The... 

Some active materials are carriers for drugs (drug delivery systems), some have immobilized peptides to enable cell adhesion or migration, some are degradable by hydrolysis or by specific enzyme action. Some contain bioactive agents (e.g., heparin, thrombomodulin) to prevent coagulation or platelet activation while others incorporate bioactive groups to enhance osteo-conduction. Many include polyethylene oxide to retard protein adsorption and this is perhaps the closest we have come to a kind of inertness. 

Trifluoroacetic acid is volatile, and thus readily removed. This acid was used by Albersheim and coworkers for the hydrolysis of plant cell-walls,39 and has since been employed for cell walls,40-43 plant mucilages,44 blood-group oligosaccharides,45 peptidogalactoman-nans,46 heparin,47 and disaccharides in blood and urine.48,49 It has also been suggested as an alternative to 6 M hydrochloric acid in the determination of amino sugars,50 and for the hydrolysis of polyalcohols produced by periodate oxidation of polysaccharides.503 Lee... 

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