Heparin, degradation kinetics

In developing a reactor such as the one just described, it is important to understand important design parameters, such as the radial distribution of the enzyme within the catalyst particles, the kinetics of heparin degradation catalyzed by immobilized heparinase, the flow properties in the reactor, and the effect of in vivo factors such as blood proteins which bind to the substrate. These parameters and how they can be evaluated are now discussed. 

The reaction rates are based on the total gel volume. The kinetics of heparin degradation [Reaction (14)] follow Michaelis-Menten kinetics (52) ... 

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