Heparin, anticoagulant drug properties

There are a number of additional targets that may lead to effective antithrombotic therapy in ACS. In terms of anticoagulants, the concepts of agents that have dual inhibitor sites such as the one we find in heparin but that lack in some of its undesirable qualities could be very useful. The same concept may apply to drugs that have both anticoagulant and antiplatelet properties, It is quite probable that inhibitors of tissue factor as well as of the platelet ADP receptor when combined with aspirin might be very effective. An ability to block the feedback action of the polyphosphates released from platelets upon activation is also an attractive aim (Fig. 3),... 

The other bioactive polysaccharide that seemed interesting to be used to produce surface-modified nanoparticles reducing their recognition by the host defense was heparin. Heparin is used as a drug for its anticoagulation properties. Additionally, it is an inhibitor of the complement activation phenomenon [116-118]. It was demonstrated that heparin-coated nanoparticles did not activate the complement system [19, 31, 32] and remained in the blood stream for a longer time compared with nanoparticles, which do not show heparin on the nanoparticle surface [89], Other polysaccharides extracted from mushrooms were found to inhibit the activation process of the complement. They could be alternative polysaccharides to produce nanoparticles with a reduced capacity to activate the complement, such as heparin [119],... 

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