Hemorrhage chronic intracranial

Streptokinase is contraindicated in patients with nlcerative wounds, active internal bleeding, recent trauma with possible internal injuries, visceral or intracranial malignancy, ulcerative cohtis, diverticulitis, severe hypertension, acute or chronic hepatic or renal insufficiency, uncontrolled hypoco-agnlation, chronic pulmonary disease with cavitation, sub-acnte bacterial endocarditis or rheumatic valvular disease, recent cerebral embolism, thrombosis, or hemorrhage, and diabetic hemorrhagic retinopathy, becanse excessive bleeding may occur. 

Eyes Erythematous, painful globe with dilated unreactive pupil (rubeosis iiidis) Papilledema Roth spot Cholesterol embolus Hypertensive or diabetic retinopathy Subhyaloid hemorrhage Ischemic eye due to combined ICA and ECA disease Increased intracranial pressure from intracranial mass, venous sinus thrombosis, hydrocephalus, chronic meningitis Bacterial endocarditis Cholesterol embolus from aorta or carotid Hypertension and/or diabetes Subarachnoid hemorrhage... 

A 40-year-old man with chronic kidney disease on phenytoin for seizme prophylaxis after an intracranial hemorrhage developed severe hypocalcemia associated with profound vitamin D deficiency. Phenytoin affects the cytochrome P450 system and can accelerate the breakdown of 25-hydroxyvitamin D3 and la,25-dihydroxyvitamin D3. Therefore, patients with chronic kidney disease may be more likely to develop hypocalcemia on phenytoin due to its effects on vitamin D metabolism [135 ]. 

---