Hemoglobin fetal mouse

Several questions remain unanswered. We do not know why the switch from fetal to adult hemoglobin in man occurs in the same cell line whereas in the tadpole and in the fetal mouse selection of a new cell line seems to occur. Experiments are in order, however, to determine whether the yolk sac erythroid cells of the fetal mouse are capable of synthesizing adult hemoglobin, whether tadpole erythrocytes are capable of synthesizing frog hemoglobin, and whether the development and differentiation of the adult erythroid lines represent irreversible loss of capacity for the synthesis of embryonic or fetal hemoglobins. 

Brotherton, T. W., D. H. Chui, J. Gauldie et al. 1979. Hemoglobin ontogeny during normal mouse fetal development. Proc Natl Acad Sci USA 76(6) 2853-7. 

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