Hemocompatible surface coating

Commercially Available Heparin-Based Hemocompatible Surface Coating... 

Weber N, Wendel H P, Ziemer G (2002). Hemocompatibility of heparin-coated surfaces and the role of selective plasma protein adsorption. Biomaterials. 23 429-439. 

The conjugation of radionuclides to HA has been proposed as an anti-proliferative therapy. The combination of the hemocompatibility of HA-coated surfaces and the anti-proliferative effects of an appropriate radiotherapy inhibited hyperplasia following revascularization procedures. Radioactive devices were obtained by... 

Improving the hemocompatibility of medically used materials via chemical modification techniques means altering the surface of the bulk material by, for example, polymerization, ligand binding, or coating. This is aimed at the development of either a bioinert or a bioactive material [6,8,10,11]. 

Another commercially available coating uses the anticoagulant heparin. Heparin coatings have two different mechanisms of imparting hemocompatibility. Heparin-releasing surfaces slowly release bound heparin, in an effective but impermanent route to hemocompatibility 19). Another way of utilizing heparin is to inunobilize the molecule by covalent linkage with the polymer surface 19, 20). 

Related results have demonstrated that CS/HA multilayer-coated NiTi disks have better antifouling properties than unmodified NiTi disks, as demonstrated by a decrease in the adhesion of platelets in an in vitro assay (38% reduction). This result may be attributable to the hydration layer that surroimds HA molecules on the surface of the disks [152]. The hydrogel-Uke surface that is formed by the multilayers exhibited good hemocompatibility. 

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