Heme-thiolate enzymes

SIBBESEN, O., KOCH, B., HALKIER, B.A., M0LLER, B.L., Cytochrome P450TYr is a multifunctional heme-thiolate enzyme catalyzing the conversion of 1-tyrosine to p-hydroxyphenylacetaldehyde oxime in the biosynthesis of the cyanogene glucoside dhurrin in Sorghum bicolor (L.) Moench, J. Biol. Chem., 1995, 270, 3506-3511. 

Conley B, Atwood DA (2003) Fluoroaluminate Chemistry 104 181-193 Contakes SM, Le Nguyen YH, Gray HB (2007) Conjugates of Heme-thiolate Enzymes with Photoactive Metal-Diimine Wires. 123... 

Conjugates of Heme-Thiolate Enzymes with Photoactive Metal-Diimine Wires... 

Sibbesen, O., Koch, B., Halkier, B.A. and Moller, B.L. (1994) Isolation of the heme-thiolate enzyme cytochrome P-450-TYR, which catalyzes the committed step in the biosynthesis of the cyanogenic glucoside, dhurrin, in Sorghum bicolor (L.). Moench. Proc. Natl. Acad. Sci. USA, 91,9740-44. 

Scheme 1.5. Pathways for oxygen-atom transfer from the active ferryl species 7 of heme-thiolate enzymes such as cytochrome P450 to form the product alcohol coordinated to the ferric, resting form of the protein (8).

Silaghi-Dumitrescu, R. (2003). Nitric oxide reduction by heme-thiolate enzymes (P450nor) A reevaluation of the mechanism. Eur. J. Inorg. Chem. 6, 1048-1052. 

Wang X, Peter S, Ullrich R, Hofiichter M, Groves JT (2013) Driving force for oxygen-atom transfer by heme-thiolate enzymes. Angew Chem Int Ed Engl 52 9238-9241... 

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