Hematotoxicity testing

Pessina, A., Malerba, 1. and Gribaldo, L. (2005) Hematotoxicity testing by cell clonogenic assay in drug development and preclinical trials. Current Pharmaceutical Design, 11, 1055-1065. 

Lead exposure surveys and other wide-scale population exposure assessments in the United States and elsewhere have largely employed PbB sampling and measurement approaches or any of several early hematotoxic effect biomarkers, such as EP and ZPP. The combination of both came into use by the 1970s. Pb testing in whole blood seemed to offer the best tradeoff... 

This chapter discusses the hematological effects of lead in both human populations and various experimental animal test systems. Lead hematotoxicity, in common with effects such as neurotoxicity, nephrotoxicity, and cardiovascular impairments, has long been recognized as accompanying chronic childhood and adult lead exposures within various Pb exposure settings. 

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